SNORD3B-2

Across TCGA pan-cancer cohorts, SNORD3B-2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SNORD3B-2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SNORD3B-2 RNA is repressed in tumor relative to normal tissue. In most cancer types SNORD3B-2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, COAD, and UCEC are the cancer types where SNORD3B-2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD3B-2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−1.797	<.001	11	view →
COAD	All	II,III,IV	+0.099	.003	5	view →
UCEC	All	All	+0.576	.031	2	view →
KICH	All	All	−0.087	.027	2	view →
LIHC	All	All	+0.082	.009	2	view →
KIRP	All	All	−0.051	.032	2	view →
HNSC	Female	III,IV	−0.343	.044	1	view →
LUSC	All	All	−0.100	.049	1	view →
CHOL	All	All	+0.075	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SNORD3B-2–THCA

Open the THCA breakdown →