Q-omics provides the consensus-scored SNORD28B profile across patient tissues and cancer cell-line models. SNORD28B expression is associated with patient survival in 9 of 34 cancer types, with the highest sampling consensus in BLCA. Among the 18 cancer types available for tumor–normal comparison, SNORD28B is differentially expressed in 1, with the highest sampling consensus in THCA. Additionally, SNORD28B RNA expression shows 11,831 significant gene co-expression associations, with the highest sampling consensus in COAD. Together, these results highlight BLCA, THCA, and COAD as cancer lineages where SNORD28B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SNORD28B — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SNORD28B survival associations across molecular data types. SNORD28B RNA expression shows survival associations in the most cancer types (9). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SNORD28B RNA expression–survival associations across cancer types. High SNORD28B expression shows unfavorable associations in BLCA, UCEC, GBM, KICH, THCA and KIRC. The BLCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify BLCA as the clearest survival context for SNORD28B RNA expression.
This table summarizes SNORD28B tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for SNORD28B. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SNORD28B shows lower tumor expression in THCA. The THCA box plot shows higher SNORD28B RNA expression in normal versus tumor tissue (log2 FC = −0.273, t-test p < 0.001).
This table shows molecular features associated with SNORD28B in patient tissues and cancer cell lines. In patient samples, SNORD28B shows the broadest associations at the RNA and protein expression levels, with COAD recurring as the lineage with the largest associated feature set.
