Across TCGA pan-cancer cohorts, SNORD12B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SNORD12B’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SNORD12B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNORD12B is over-expressed in tumor.
KIRC, COAD, and LIHC are the cancer types where SNORD12B tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD12B RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.