Q-omics provides the consensus-scored SNORD12B profile across patient tissues and cancer cell-line models. SNORD12B expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, SNORD12B is differentially expressed in 14, with the highest sampling consensus in KIRC. Additionally, SNORD12B RNA expression shows 16,424 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRC, and UVM as cancer lineages where SNORD12B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SNORD12B — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SNORD12B survival associations across molecular data types. SNORD12B RNA expression shows survival associations in the most cancer types (24). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SNORD12B RNA expression–survival associations across cancer types. High SNORD12B expression shows unfavorable associations in KIRC, KIRP, ACC, STAD and UVM, but favorable associations in BRCA. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for SNORD12B RNA expression.
This table summarizes SNORD12B tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for SNORD12B. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SNORD12B shows higher tumor expression in KIRC, COAD, LIHC, STAD, LUAD and READ. The KIRC box plot shows higher SNORD12B RNA expression in tumor versus normal tissue (log2 FC = +0.691, t-test p < 0.001).
This table shows molecular features associated with SNORD12B in patient tissues and cancer cell lines. In patient samples, SNORD12B shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
