Across TCGA pan-cancer cohorts, SNORD116-8 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SNORD116-8’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SNORD116-8 RNA is repressed in tumor relative to normal tissue. In most cancer types SNORD116-8 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA and KIRP are the cancer types where SNORD116-8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD116-8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.416	<.001	6	view →
KIRP	Male	All	−0.102	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SNORD116-8 RNA expression & survival · all SNORD116-8 data types