Across TCGA patient cohorts, SNORD116-5 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SNORD116-5-associated genes across cancer lineages are GTF3AP1, RN7SL541P, and MRPL42P4. Each is linked with SNORD116-5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNORD116-5-to-partner and partner-to-SNORD116-5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNORD116-5→partner) and Y-score (partner→SNORD116-5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GTF3AP1 →	+0.070	+6.080	<.001	.002	3	1
SKCM	RN7SL541P →	+0.209	+5.159	<.001	.007	3	1
SKCM	MRPL42P4 →	+0.101	+5.867	<.001	.003	3	1
LUSC	RNU6-1059P →	+0.217	+7.924	<.001	.008	3	1
LUSC	RNU6-348P →	+0.203	+7.924	<.001	.008	3	1
LUSC	RNA5SP501 →	+0.196	+7.924	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

SNORD116-5 survival (RNA) · tumor vs normal (RNA) · all SNORD116-5 data types