Across TCGA pan-cancer cohorts, SNORD116-4 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SNORD116-4 data layer compared with 23 for mass-spec protein.
The strongest signal is observed in uterine carcinosarcoma (UCS), where higher SNORD116-4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD116-4 expression acts as an unfavorable survival marker.
UCS and LGG are the cancer types where SNORD116-4 Mutation most reproducibly stratifies survival.