SNORD116-30

Across TCGA pan-cancer cohorts, SNORD116-30 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SNORD116-30’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SNORD116-30 RNA is repressed in tumor relative to normal tissue. In most cancer types SNORD116-30 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, PRAD, and BRCA are the cancer types where SNORD116-30 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD116-30 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.244	.017	3	view →
PRAD	All	All	+0.240	.041	2	view →
BRCA	Female	All	+0.179	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

SNORD116-30–THCA

Open the THCA breakdown →