SNORD116-28

Across TCGA patient cohorts, SNORD116-28 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SNORD116-28-associated genes across cancer lineages are RNU6-281P, OFD1P11Y, and MIR3152. Each is linked with SNORD116-28 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNORD116-28-to-partner and partner-to-SNORD116-28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-281P grouped by SNORD116-28-low versus SNORD116-28-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNORD116-28→partner) and Y-score (partner→SNORD116-28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-281P →	+0.373	+7.816	<.001	.008	3	1
SKCM	OFD1P11Y →	+0.039	+7.816	<.001	.008	3	1
SKCM	MIR3152 →	+0.478	+7.816	<.001	.008	3	1
SKCM	MRPS5P4 →	+0.139	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

RNU6-281P by SNORD116-28 expression — SKCM

Explore this box plot interactively →