SNORD116-27

Across TCGA pan-cancer cohorts, SNORD116-27 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated SNORD116-27 data layer compared with 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SNORD116-27 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD116-27 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCEC show a favorable association.

HNSC, STAD, and DLBC are the cancer types where SNORD116-27 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.235	0.589	<.001	117	view →
STAD	DFS	Tertile	All	0.427	0.588	.003	75	view →
DLBC	DFS	Tertile	All	0.466	0.872	.001	73	view →
UVM	DFS	Tertile	All	0.118	0.794	<.001	45	view →
BLCA	OS	Tertile	IV	0.092	0.607	<.001	36	view →
CHOL	DFS	Median	All	0.108	0.637	.006	29	view →
PAAD	DFS	Tertile	II,III,IV	0.278	0.472	.007	27	view →
ACC	DFS	Tertile	All	0.430	0.776	.032	21	view →
KIRC	OS	Quartile	All	0.747	0.592	.004	13	view →
UCEC	OS	Tertile	II,III,IV	0.900	0.740	.034	12	view →
LIHC	OS	Tertile	All	0.351	0.531	.034	6	view →
SARC	OS	Tertile	All	0.673	0.438	.018	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

SNORD116-27–HNSC (OS)

Open the HNSC breakdown →