SNORD116-27

Across TCGA pan-cancer cohorts, SNORD116-27 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SNORD116-27’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SNORD116-27 RNA is repressed in tumor relative to normal tissue. In most cancer types SNORD116-27 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, PRAD, and KICH are the cancer types where SNORD116-27 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD116-27 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.505	.001	5	view →
PRAD	All	All	+0.387	.026	2	view →
KICH	All	All	−0.330	.041	2	view →
LUAD	All	All	+0.304	.034	2	view →
ESCA	All	All	−0.502	.032	1	view →
KIRC	Male	III,IV	−0.279	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SNORD116-27–THCA

Open the THCA breakdown →