SNORD116-26

Across TCGA pan-cancer cohorts, SNORD116-26 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated SNORD116-26 data layer compared with 1 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher SNORD116-26 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD116-26 expression acts as an unfavorable survival marker, although some lineages such as PCPG and BRCA show a favorable association.

MESO, READ, and STAD are the cancer types where SNORD116-26 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	IV	0.056	0.640	<.001	84	view →
READ	DFS	Tertile	III,IV	0.490	0.765	.010	33	view →
STAD	OS	Tertile	III,IV	0.307	0.574	.025	24	view →
ACC	DFS	Tertile	All	0.382	0.687	.007	24	view →
KICH	DFS	Median	III,IV	0.373	1.000	.009	17	view →
LUSC	DFS	Tertile	II,III,IV	0.212	0.417	.016	12	view →
HNSC	DFS	Tertile	III,IV	0.214	0.517	.023	9	view →
LGG	OS	Tertile	All	0.426	0.628	.013	8	view →
PCPG	DFS	Quartile	All	1.000	0.696	.028	7	view →
DLBC	OS	Tertile	All	0.219	0.903	.028	6	view →
BRCA	DFS	Tertile	III,IV	0.880	0.770	.041	6	view →
KIRC	DFS	Quartile	III,IV	0.888	0.655	.016	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

SNORD116-26–MESO (OS)

Open the MESO breakdown →