SNORD116-26

Across TCGA pan-cancer cohorts, SNORD116-26 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SNORD116-26’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SNORD116-26 RNA is repressed in tumor relative to normal tissue. In most cancer types SNORD116-26 is over-expressed in tumor, although a few such as THCA and STAD show the opposite, repressed pattern.

THCA, STAD, and UCEC are the cancer types where SNORD116-26 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD116-26 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.563	<.001	6	view →
STAD	All	All	−0.406	.001	6	view →
UCEC	All	IV	−1.270	.001	2	view →
KIRP	Male	All	−0.373	.009	2	view →
PRAD	All	All	+0.267	.047	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SNORD116-26–THCA

Open the THCA breakdown →