SNORD116-23

Across TCGA pan-cancer cohorts, SNORD116-23 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated SNORD116-23 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher SNORD116-23 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNORD116-23 expression acts as an unfavorable survival marker, although some lineages such as BRCA and ESCA show a favorable association.

KICH, LUAD, and STAD are the cancer types where SNORD116-23 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.186	0.874	<.001	72	view →
LUAD	DFS	Tertile	II,III,IV	0.321	0.560	.001	63	view →
STAD	OS	Tertile	All	0.140	0.592	<.001	57	view →
LIHC	OS	Tertile	II,III,IV	0.307	0.709	.003	45	view →
ACC	OS	Tertile	All	0.133	0.686	.004	36	view →
PAAD	OS	Tertile	All	0.421	0.634	.005	33	view →
UVM	DFS	Tertile	All	0.079	0.746	<.001	27	view →
READ	DFS	Tertile	All	0.162	0.720	.019	27	view →
SKCM	DFS	Tertile	All	0.365	0.656	.002	21	view →
SARC	DFS	Tertile	All	0.353	0.597	.020	18	view →
BRCA	DFS	Tertile	III,IV	1.000	0.473	.046	6	view →
ESCA	OS	Tertile	All	0.787	0.490	.039	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

SNORD116-23–KICH (DFS)

Open the KICH breakdown →