SNORD116-23

Across TCGA pan-cancer cohorts, SNORD116-23 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SNORD116-23’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SNORD116-23 RNA is repressed in tumor relative to normal tissue. In most cancer types SNORD116-23 is over-expressed in tumor, although a few such as THCA and STAD show the opposite, repressed pattern.

THCA and STAD are the cancer types where SNORD116-23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD116-23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−0.391	.009	3	view →
STAD	Female	III,IV	−1.174	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

SNORD116-23–THCA

Open the THCA breakdown →