Across TCGA pan-cancer cohorts, SNORD116-13 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SNORD116-13’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SNORD116-13 RNA is repressed in tumor relative to normal tissue. In most cancer types SNORD116-13 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, KICH, and BRCA are the cancer types where SNORD116-13 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD116-13 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.684	<.001	5	view →
KICH	All	III,IV	+0.610	.017	2	view →
BRCA	All	III,IV	−0.443	<.001	2	view →
PRAD	All	All	+0.304	.044	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SNORD116-13 RNA expression & survival · all SNORD116-13 data types