SNORD115-46

Across TCGA pan-cancer cohorts, SNORD115-46 RNA is linked to patient survival in 5 of 34 cancer types, making it the most broadly survival-associated SNORD115-46 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher SNORD115-46 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD115-46 expression acts as an unfavorable survival marker, although some lineages such as ESCA show a favorable association.

LIHC, LUAD, and THCA are the cancer types where SNORD115-46 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.051	0.783	<.001	108	view →
LUAD	OS	Tertile	All	0.223	0.812	<.001	81	view →
THCA	OS	Tertile	III,IV	0.290	0.897	.002	42	view →
LGG	DFS	Tertile	All	0.267	0.742	<.001	42	view →
ESCA	DFS	Tertile	III,IV	1.000	0.281	.043	12	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SNORD115-46–LIHC (OS)

Open the LIHC breakdown →