Across TCGA pan-cancer cohorts, SNORD115-45 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated SNORD115-45 data layer.
The strongest signal is observed in brain lower grade glioma (LGG), where higher SNORD115-45 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SNORD115-45 expression acts as an unfavorable survival marker, although some lineages such as LGG and PAAD show a favorable association.
LGG, UCEC, and ACC are the cancer types where SNORD115-45 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.