Across TCGA pan-cancer cohorts, SNORD115-45 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SNORD115-45’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SNORD115-45 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNORD115-45 is over-expressed in tumor, although a few such as KIRP show the opposite, repressed pattern.

THCA, KIRP, and BRCA are the cancer types where SNORD115-45 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD115-45 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	+0.376	.003	5	view →
KIRP	Male	All	−0.247	.024	2	view →
BRCA	Female	All	+0.174	.044	2	view →
KIRC	All	All	+0.151	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SNORD115-45 RNA expression & survival · all SNORD115-45 data types