Across TCGA pan-cancer cohorts, SNORD115-22 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SNORD115-22 data layer compared with 7 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher SNORD115-22 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNORD115-22 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

LUSC and SKCM are the cancer types where SNORD115-22 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.079	0.792	<.001	30	view →
SKCM	DFS	Median	III,IV	1.000	0.249	.034	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SNORD115-22 tumor-vs-normal RNA expression · all SNORD115-22 data types