Across TCGA pan-cancer cohorts, SNORD115-21 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SNORD115-21 data layer compared with 11 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SNORD115-21 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD115-21 expression acts as an unfavorable survival marker.

HNSC and LUAD are the cancer types where SNORD115-21 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.139	0.685	.003	24	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SNORD115-21 tumor-vs-normal RNA expression · all SNORD115-21 data types