Across TCGA pan-cancer cohorts, SNORD115-21 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SNORD115-21’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SNORD115-21 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNORD115-21 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

KICH and KIRC are the cancer types where SNORD115-21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD115-21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	+0.266	.007	2	view →
KIRC	Male	All	−0.063	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SNORD115-21 RNA expression & survival · all SNORD115-21 data types