Across TCGA patient cohorts, SNORD115-21 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SNORD115-21-associated genes across cancer lineages are RCC2P2, COX6B1P2, and RNU6-245P. Each is linked with SNORD115-21 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNORD115-21-to-partner and partner-to-SNORD115-21 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNORD115-21→partner) and Y-score (partner→SNORD115-21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RCC2P2 →	+0.121	+5.292	<.001	.006	3	1
SKCM	COX6B1P2 →	+0.215	+5.292	<.001	.006	3	1
LUSC	RNU6-245P →	+0.483	+4.984	<.001	.009	3	1
LUSC	EIF4EBP2P1 →	+0.286	+5.404	<.001	.005	3	1
LUSC	RPL38P1 →	+0.185	+5.151	.003	.007	3	1
LUSC	PHBP15 →	+0.064	+5.548	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

SNORD115-21 survival (RNA) · tumor vs normal (RNA) · all SNORD115-21 data types