SNORD115-17

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SNORD115-17 mutation is significantly associated with the RNA expression of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNORD115-17-associated genes across cancer lineages are GAPDHP41, TPRX1, and CYCSP51. Each is linked with SNORD115-17 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNORD115-17-to-partner and partner-to-SNORD115-17 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNORD115-17→partner) and Y-score (partner→SNORD115-17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECGAPDHP41 →+0.373+4.078<.001.00532
LUSCTPRX1 →+0.140+3.651<.001.00332
LUSCCYCSP51 →+0.371+3.906<.001.00432
UCECTMEM271 →+0.476+4.262<.001.00331
UCECRN7SL627P →+0.144+4.442<.001.00731
LUADTRIM51HP →+0.076+5.279<.001.00631
Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

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