Across TCGA pan-cancer cohorts, SNORD113-4 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SNORD113-4 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher SNORD113-4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD113-4 expression acts as an unfavorable survival marker, although some lineages such as LAML and PAAD show a favorable association.

THCA, MESO, and LUSC are the cancer types where SNORD113-4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	II,III,IV	0.698	0.967	<.001	66	view →
MESO	OS	Tertile	All	0.419	0.623	.001	59	view →
LUSC	DFS	Tertile	II,III,IV	0.464	0.630	.019	39	view →
BRCA	DFS	Tertile	All	0.570	1.000	.033	36	view →
LUAD	DFS	Tertile	IV	0.109	0.714	.001	36	view →
UCEC	OS	Tertile	All	0.734	0.881	.004	36	view →
LAML	DFS	Tertile	All	0.630	0.322	.012	30	view →
ACC	OS	Quartile	All	0.588	0.965	<.001	29	view →
BLCA	OS	Tertile	All	0.469	0.630	.010	27	view →
PAAD	DFS	Median	All	0.501	0.272	.012	17	view →
PCPG	DFS	Median	All	0.949	0.657	.005	10	view →
LIHC	DFS	Tertile	II,III,IV	0.232	0.481	.047	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

Exploration

Same gene, other analysis: SNORD113-4 tumor-vs-normal RNA expression · all SNORD113-4 data types