Across TCGA pan-cancer cohorts, SNORD113-4 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SNORD113-4’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where SNORD113-4 RNA is repressed in tumor relative to normal tissue. In most cancer types SNORD113-4 is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

UCEC, BRCA, and HNSC are the cancer types where SNORD113-4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD113-4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	All	−0.516	.004	4	view →
BRCA	All	III,IV	−0.452	<.001	2	view →
HNSC	All	IV	−0.268	.036	2	view →
KIRC	All	II,III,IV	−0.072	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SNORD113-4 RNA expression & survival · all SNORD113-4 data types