SNORA59B

Across TCGA pan-cancer cohorts, SNORA59B RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of SNORA59B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SNORA59B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNORA59B is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

KIRC, LIHC, and UCEC are the cancer types where SNORA59B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORA59B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	+0.207	<.001	9	view →
LIHC	Male	All	+0.628	<.001	6	view →
UCEC	All	All	+0.204	.012	6	view →
THCA	Female	All	+0.130	<.001	5	view →
LUSC	All	All	−0.044	.011	3	view →
KICH	All	II,III,IV	−0.078	.026	2	view →
BRCA	All	III,IV	−0.031	.041	2	view →
CHOL	Female	All	+0.653	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

SNORA59B–KIRC

Open the KIRC breakdown →