Across TCGA pan-cancer cohorts, SNORA53 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SNORA53 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher SNORA53 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SNORA53 expression acts as an unfavorable survival marker, although some lineages such as LIHC and UCS show a favorable association.

LIHC, KIRC, and LGG are the cancer types where SNORA53 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	II,III,IV	0.809	0.614	<.001	42	view →
KIRC	DFS	Quartile	III,IV	0.332	0.615	.005	24	view →
LGG	DFS	Quartile	All	0.741	0.862	.004	20	view →
ACC	OS	Median	III,IV	0.177	0.753	.002	16	view →
THCA	DFS	Quartile	II,III,IV	0.885	0.964	.015	15	view →
UCS	DFS	Tertile	IV	0.956	0.381	.024	12	view →
LUAD	DFS	Quartile	III,IV	0.785	0.519	.037	12	view →
STAD	DFS	Tertile	All	0.426	0.624	.038	6	view →
GBM	DFS	Median	All	0.193	0.283	.029	6	view →
ESCA	DFS	Median	II,III,IV	0.455	0.583	.038	6	view →
UVM	DFS	Quartile	III,IV	0.401	0.849	.018	5	view →
KIRP	DFS	Median	III,IV	0.539	0.862	.008	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

Exploration

Same gene, other analysis: SNORA53 tumor-vs-normal RNA expression · all SNORA53 data types