SNIP1

Across TCGA patient cohorts, SNIP1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNIP1-associated genes across cancer lineages are INPP4B, EGFR_pY1068, and MEK1. Each is linked with SNIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNIP1-to-partner and partner-to-SNIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SNIP1-low versus SNIP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNIP1→partner) and Y-score (partner→SNIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.529	-3.000	.006	.035	3	2
UCEC	EGFR_pY1068 →	-0.209	-1.584	.034	.036	3	2
UCEC	MEK1 →	+0.556	+2.502	<.001	.002	3	2
UCEC	PDCD4 →	-0.676	-2.000	<.001	.010	3	2
COAD	PAI-1 →	+0.950	+3.008	.001	.019	3	1
COAD	ASNS →	+0.714	+3.008	<.001	.019	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

INPP4B by SNIP1 expression — COAD

Explore this box plot interactively →