SNHG22

Across TCGA pan-cancer cohorts, SNHG22 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SNHG22 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SNHG22 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SNHG22 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

BRCA, SKCM, and KIRC are the cancer types where SNHG22 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	II,III,IV	0.937	0.885	.003	47	view →
SKCM	OS	Quartile	All	0.395	0.247	<.001	32	view →
KIRC	DFS	Tertile	II,III,IV	0.516	0.759	.012	20	view →
LUAD	OS	Tertile	II,III,IV	0.561	0.783	.012	19	view →
MESO	DFS	Median	III,IV	0.674	0.228	.002	15	view →
PRAD	DFS	Tertile	All	0.853	0.937	.008	14	view →
LGG	DFS	Tertile	All	0.636	0.797	<.001	13	view →
ACC	DFS	Tertile	III,IV	0.090	0.603	.008	9	view →
THCA	DFS	Tertile	III,IV	0.824	0.962	.014	9	view →
LIHC	OS	Median	All	0.775	0.631	.009	7	view →
GBM	OS	Quartile	All	0.564	0.234	.001	6	view →
OV	OS	Quartile	IV	0.527	0.921	.013	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SNHG22–BRCA (OS)

Open the BRCA breakdown →