SNCG

Across TCGA pan-cancer cohorts, SNCG mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SNCG data layer compared with 28 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SNCG mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SNCG expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where SNCG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	II,III,IV	0.697	0.960	.006	20	view →
HNSC	OS	Median	All	0.933	1.000	.002	15	view →
PDAC	OS	Quartile	II,III,IV	0.748	0.954	.004	11	view →
LUAD	OS	Median	All	0.919	0.999	.009	6	view →
UCEC	OS	Median	All	0.853	0.969	.030	4	view →
LSCC	DFS	Quartile	All	1.000	0.465	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SNCG–CCRCC (OS)

Open the CCRCC breakdown →