SNCG

Across TCGA pan-cancer cohorts, SNCG RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SNCG’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SNCG RNA is repressed in tumor relative to normal tissue. In most cancer types SNCG is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

COAD, LIHC, and LUSC are the cancer types where SNCG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNCG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−1.732	<.001	9	view →
LIHC	All	II,III,IV	+2.520	<.001	8	view →
LUSC	All	III,IV	−2.098	<.001	7	view →
KIRC	Male	III,IV	+1.292	<.001	7	view →
UCEC	All	II,III,IV	−4.189	<.001	6	view →
BRCA	All	II,III,IV	−2.782	<.001	6	view →
KICH	Female	All	−2.155	<.001	6	view →
CHOL	Female	All	+3.266	<.001	3	view →
READ	Female	All	−2.897	<.001	2	view →
PRAD	All	All	−2.130	<.001	2	view →
STAD	All	All	−0.821	.026	2	view →
LUAD	All	II,III,IV	+0.731	.048	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SNCG–COAD

Open the COAD breakdown →