SNCG

Across TCGA patient cohorts, SNCG mutation is significantly associated with the RNA expression of many other genes, with 363 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNCG-associated genes across cancer lineages are MLLT10P2, LINC01792, and AP1S2P1. Each is linked with SNCG in more than 1 cancer types. Because this analysis shows association rather than direction, both SNCG-to-partner and partner-to-SNCG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MLLT10P2 grouped by SNCG-low versus SNCG-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNCG→partner) and Y-score (partner→SNCG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MLLT10P2 →	+0.113	+5.469	<.001	.002	3	2
UCEC	LINC01792 →	+0.097	+2.635	<.001	.002	3	2
SKCM	AP1S2P1 →	+0.098	+4.594	<.001	.008	3	2
UCEC	FXYD4 →	+1.933	+3.480	<.001	.002	3	1
UCEC	PRSS53 →	+0.391	+3.254	<.001	.008	3	1
UCEC	TXNDC11 →	+0.492	+3.346	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 363 associations by consensus.

MLLT10P2 by SNCG expression — SKCM

Explore this box plot interactively →