SNCG

Across TCGA patient cohorts, SNCG mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNCG-associated genes across cancer lineages are ERK2, GAPDH, and MAPK_pT202_Y204. Each is linked with SNCG in more than 1 cancer types. Because this analysis shows association rather than direction, both SNCG-to-partner and partner-to-SNCG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SNCG-low versus SNCG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNCG→partner) and Y-score (partner→SNCG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.198	+2.321	.041	.035	3	1
UCEC	GAPDH →	+0.584	+3.321	.030	.010	3	1
UCEC	MAPK_pT202_Y204 →	-0.582	-2.321	.013	.035	3	1
UCEC	mTOR_pS2448 →	-0.215	-2.986	.004	.035	3	1
UCEC	Src_pY527 →	-0.508	-2.321	.018	.035	3	1
UCEC	Src →	+0.256	+2.833	.013	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ERK2 by SNCG expression — UCEC

Explore this box plot interactively →