SNCG

Across TCGA cell cohorts, SNCG RNA expression is significantly associated with the go_rna of many other GO terms, with 3,526 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SNCG-associated GO terms across cancer lineages are Small GTPase-mediated signal transduction, Chaperone-mediated autophagy, and Cellular response to indole-3-methanol. Each is linked with SNCG in more than 8 cancer types. Because this analysis shows association rather than direction, both SNCG-to-partner and partner-to-SNCG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Small GTPase-mediated signal transduction grouped by SNCG-low versus SNCG-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SNCG→partner) and Y-score (partner→SNCG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Small GTPase-mediated signal transduction →	+0.056	+2.891	<.001	.003	3	9
LUNG_NSCLC_LUSC	Chaperone-mediated autophagy →	+0.115	+2.756	.002	.004	3	9
URINARY_TRACT	Cellular response to indole-3-methanol →	+0.222	+5.164	<.001	<.001	3	9
URINARY_TRACT	Response to steroid hormone →	+0.080	+4.417	.001	.001	3	8
LARGE_INTESTINE	Cellular response to folic acid →	+1.175	+2.113	<.001	<.001	3	8
BONE	Negative regulation of protein tyrosine kinase activity →	+0.124	+1.541	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,526 associations by consensus.

Small GTPase-mediated signal transduction by SNCG expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →