SNCB

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SNCB protein abundance is significantly associated with the RNA expression of many other genes, with 3,860 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SNCB-associated genes across cancer lineages are SYP, RNF130, and SLC12A5. Each is linked with SNCB in more than 1 cancer types. Because this analysis shows association rather than direction, both SNCB-to-partner and partner-to-SNCB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SNCB versus SYP in GBM, with a Pearson correlation of 0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNCB→partner) and Y-score (partner→SNCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMSYP →+1.420+0.938<.001<.00132
OVRNF130 →+1.039+2.007.004.00532
GBMSLC12A5 →+1.595+0.969<.001<.00132
OVFFAR1 →+0.673+2.433<.001.00932
GBMGAPDHP33 →+0.646+0.827<.001<.00132
OVLINC01574 →+1.452+2.007.008.00532
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,860 associations by consensus.

SNCB vs SYP — GBM

Per-sample scatter of SNCB vs SYP in GBM (Pearson r = 0.65).

Explore this scatter interactively →

Exploration