SNCB

Across TCGA patient cohorts, SNCB mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNCB-associated genes across cancer lineages are Annexin-1, EGFR_pY1068, and A-Raf_pS299. Each is linked with SNCB in more than 1 cancer types. Because this analysis shows association rather than direction, both SNCB-to-partner and partner-to-SNCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by SNCB-low versus SNCB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNCB→partner) and Y-score (partner→SNCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.659	+3.019	.007	.019	3	2
UCEC	EGFR_pY1068 →	-0.290	-3.169	.013	.019	3	1
UCEC	A-Raf_pS299 →	-0.157	-3.169	.004	.019	3	1
UCEC	ERK2 →	+0.203	+2.999	.024	.035	3	1
UCEC	MEK1 →	+0.516	+3.321	.002	.010	3	1
UCEC	p70-S6K_pT389 →	-0.249	-2.312	.005	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Annexin-1 by SNCB expression — UCEC

Explore this box plot interactively →