SNCA

Across TCGA pan-cancer cohorts, SNCA Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SNCA data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SNCA Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SNCA expression acts as an unfavorable survival marker.

LUAD, LGG, and SKCM are the cancer types where SNCA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.167	0.668	<.001	18	view →
LGG	OS	Median	All	0.194	0.830	<.001	12	view →
SKCM	DFS	Median	III,IV	0.088	0.613	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SNCA–LUAD (OS)

Open the LUAD breakdown →