SNCA

Across TCGA pan-cancer cohorts, SNCA mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SNCA data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SNCA mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SNCA expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, UCEC, and HNSC are the cancer types where SNCA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.964	0.655	<.001	27	view →
UCEC	DFS	Quartile	III,IV	0.355	1.000	.040	16	view →
HNSC	DFS	Tertile	All	1.000	0.905	.012	15	view →
LUAD	DFS	Tertile	III,IV	0.279	0.861	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SNCA–CCRCC (DFS)

Open the CCRCC breakdown →