SNAPIN

Across TCGA patient cohorts, SNAPIN protein abundance is significantly associated with the protein abundance of many other proteins, with 19,507 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SNAPIN-associated proteins across cancer lineages are BLOC1S2, BORCS5, and BLOC1S1. Each is linked with SNAPIN in more than 8 cancer types. Because this analysis shows association rather than direction, both SNAPIN-to-partner and partner-to-SNAPIN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SNAPIN versus BLOC1S2 in PDAC, with a Pearson correlation of 0.66.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SNAPIN→partner) and Y-score (partner→SNAPIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	BLOC1S2 →	+0.370	+0.259	<.001	<.001	3	9
OV	BORCS5 →	+0.336	+0.199	<.001	<.001	3	9
PDAC	BLOC1S1 →	+0.591	+0.297	<.001	<.001	3	8
GBM	DTNBP1 →	+0.352	+0.312	<.001	<.001	3	8
HNSC	COMMD9 →	+0.328	+0.283	<.001	<.001	3	7
PDAC	BLOC1S3 →	+0.348	+0.409	<.001	<.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,507 associations by consensus.

SNAPIN vs BLOC1S2 — PDAC

Explore this scatter interactively →