SNAPC4

Across TCGA patient cohorts, SNAPC4 mutation is significantly associated with the RNA expression of many other genes, with 1,347 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNAPC4-associated genes across cancer lineages are PBK, SKA1, and HASPIN. Each is linked with SNAPC4 in more than 4 cancer types. Because this analysis shows association rather than direction, both SNAPC4-to-partner and partner-to-SNAPC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PBK grouped by SNAPC4-low versus SNAPC4-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNAPC4→partner) and Y-score (partner→SNAPC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	PBK →	+0.717	+3.331	.002	.005	3	4
UCEC	SKA1 →	+0.665	+3.931	<.001	<.001	3	4
UCEC	HASPIN →	+0.673	+2.815	.001	.001	3	4
STAD	PTMAP4 →	+1.113	+3.195	<.001	.009	2	5
CESC	KXD1 →	+0.315	+3.371	.006	.004	3	3
CESC	PLA2G4A →	+1.753	+3.371	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,347 associations by consensus.

PBK by SNAPC4 expression — CESC

Explore this box plot interactively →