SNAPC4

Across TCGA patient cohorts, SNAPC4 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNAPC4-associated genes across cancer lineages are Chk1, Notch1, and 4E-BP1. Each is linked with SNAPC4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SNAPC4-to-partner and partner-to-SNAPC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1 grouped by SNAPC4-low versus SNAPC4-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNAPC4→partner) and Y-score (partner→SNAPC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	Chk1 →	+0.329	+2.842	.027	.032	3	4
COAD	Notch1 →	+0.189	+3.178	.038	.010	3	3
UCEC	4E-BP1 →	+0.424	+3.169	<.001	.018	3	3
UCEC	MEK1 →	+0.433	+2.115	.005	.017	3	2
UCEC	Collagen-VI →	-0.217	-3.446	.013	.005	3	2
STAD	Src_pY416 →	+0.373	+3.169	.018	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Chk1 by SNAPC4 expression — CESC

Explore this box plot interactively →