SNAPC4

Across TCGA cell cohorts, SNAPC4 mutation is significantly associated with the RNA expression of many other genes, with 425 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SNAPC4-associated genes across cancer lineages are TM4SF5, TSPO2, and OFCC1. Each is linked with SNAPC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SNAPC4-to-partner and partner-to-SNAPC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TM4SF5 grouped by SNAPC4-low versus SNAPC4-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNAPC4→partner) and Y-score (partner→SNAPC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TM4SF5 →	+0.096	+2.843	<.001	.004	3	3
SOFT_TISSUE	TSPO2 →	+0.071	+3.865	<.001	.006	3	2
SOFT_TISSUE	OFCC1 →	+0.418	+4.000	<.001	.004	3	2
SOFT_TISSUE	TCP11X2 →	+0.008	+4.392	<.001	.004	3	2
SOFT_TISSUE	PAGE1 →	+0.658	+3.999	.005	.004	3	2
KIDNEY	DEFB108B →	+0.080	+5.000	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 425 associations by consensus.

TM4SF5 by SNAPC4 expression — BLOOD_Lymphoma

Explore this box plot interactively →