SNAPC1

Across TCGA cell cohorts, SNAPC1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SNAPC1-associated genes across cancer lineages are GCM2, CLEC4F, and WDR87. Each is linked with SNAPC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNAPC1-to-partner and partner-to-SNAPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCM2 grouped by SNAPC1-low versus SNAPC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNAPC1→partner) and Y-score (partner→SNAPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCM2 →	+0.048	+2.657	.002	.007	3	1
LARGE_INTESTINE	CLEC4F →	+0.242	+3.237	<.001	.001	3	1
LARGE_INTESTINE	WDR87 →	+0.019	+3.353	<.001	.004	3	1
LARGE_INTESTINE	KCNIP1 →	+0.041	+3.472	.003	.005	3	1
LARGE_INTESTINE	DEFA1 →	+0.238	+2.657	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

GCM2 by SNAPC1 expression — LARGE_INTESTINE

Explore this box plot interactively →