SNAP25

Across TCGA pan-cancer cohorts, SNAP25 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SNAP25 data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SNAP25 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNAP25 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

CCRCC, PDAC, and GBM are the cancer types where SNAP25 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.093	1.000	.024	13	view →
PDAC	OS	Median	II,III,IV	0.524	0.216	.017	11	view →
GBM	DFS	Quartile	All	0.856	0.636	.018	4	view →
HNSC	DFS	Median	IV	0.432	0.809	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SNAP25–CCRCC (DFS)

Open the CCRCC breakdown →