SNAP25

Across TCGA pan-cancer cohorts, SNAP25 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SNAP25’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SNAP25 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNAP25 is over-expressed in tumor, although a few such as COAD and UCEC show the opposite, repressed pattern.

KIRC, COAD, and THCA are the cancer types where SNAP25 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNAP25 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.717	<.001	11	view →
COAD	Male	II,III,IV	−1.547	<.001	11	view →
THCA	Male	III,IV	+1.361	<.001	11	view →
HNSC	All	III,IV	+0.330	<.001	10	view →
UCEC	All	III,IV	−3.413	<.001	8	view →
KIRP	Male	III,IV	+2.162	<.001	7	view →
KICH	Female	All	−1.220	<.001	5	view →
READ	Female	All	−2.357	<.001	4	view →
LIHC	All	II,III,IV	+0.807	.021	4	view →
CHOL	Female	All	+4.330	<.001	3	view →
PRAD	All	All	−1.431	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SNAP25–KIRC

Open the KIRC breakdown →