SNAP25

Across TCGA patient cohorts, SNAP25 mutation is significantly associated with the RNA expression of many other genes, with 3,521 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNAP25-associated genes across cancer lineages are RN7SL383P, IGHD1-1, and RADIL. Each is linked with SNAP25 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNAP25-to-partner and partner-to-SNAP25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL383P grouped by SNAP25-low versus SNAP25-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNAP25→partner) and Y-score (partner→SNAP25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RN7SL383P →	+0.219	+5.352	<.001	.005	3	2
BRCA	IGHD1-1 →	+1.280	+4.386	.003	.007	3	2
UCEC	RADIL →	-0.390	-2.764	.005	.003	3	2
UCEC	CD2BP2 →	+0.325	+2.906	.001	.001	3	2
UCEC	KIF22 →	+0.437	+2.906	.001	.001	3	2
UCEC	UBE2I →	+0.369	+1.968	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,521 associations by consensus.

RN7SL383P by SNAP25 expression — GBM

Explore this box plot interactively →