SNAP25

Across TCGA patient cohorts, SNAP25 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNAP25-associated genes across cancer lineages are Rb, EGFR_pY1068, and eIF4E. Each is linked with SNAP25 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNAP25-to-partner and partner-to-SNAP25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rb grouped by SNAP25-low versus SNAP25-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNAP25→partner) and Y-score (partner→SNAP25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Rb →	+0.201	+2.321	.011	.035	3	2
UCEC	EGFR_pY1068 →	-0.238	-2.415	.003	.002	3	1
UCEC	eIF4E →	+0.146	+1.765	.033	.013	3	1
UCEC	ERK2 →	+0.169	+2.000	.006	.009	3	1
UCEC	FOXO3a_pS318_S321 →	-0.082	-1.222	.043	.035	3	1
UCEC	JNK2 →	+0.182	+1.716	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Rb by SNAP25 expression — SKCM

Explore this box plot interactively →