SNAP25

Across TCGA cell cohorts, SNAP25 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,678 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SNAP25-associated GO terms across cancer lineages are Establishment of protein localization to organelle, Vesicle cargo loading, and Positive regulation of translational initiation. Each is linked with SNAP25 in more than 8 cancer types. Because this analysis shows association rather than direction, both SNAP25-to-partner and partner-to-SNAP25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of protein localization to organelle grouped by SNAP25-low versus SNAP25-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SNAP25→partner) and Y-score (partner→SNAP25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Establishment of protein localization to organelle →	+0.029	+1.264	.003	.004	3	9
SKIN	Vesicle cargo loading →	+0.097	+1.614	<.001	.002	3	7
CNS	Positive regulation of translational initiation →	+0.070	+1.268	<.001	.002	3	7
PANCREAS	Potassium ion import across plasma membrane →	-0.178	-1.227	<.001	.002	3	7
LUNG_NSCLC_LUAD	DNA-templated transcription initiation →	+0.024	+1.009	.002	.006	3	7
BREAST	Action potential propagation →	+0.848	+1.016	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,678 associations by consensus.

Establishment of protein localization to organelle by SNAP25 expression — SKIN

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