SNAP23

Across TCGA pan-cancer cohorts, SNAP23 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SNAP23 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SNAP23 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNAP23 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where SNAP23 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	IV	0.131	0.861	.001	18	view →
LUAD	DFS	Median	II,III,IV	0.773	1.000	.005	6	view →
PDAC	DFS	Median	III,IV	0.531	0.220	.032	5	view →
UCEC	OS	Quartile	All	1.000	0.880	.035	4	view →
LSCC	OS	Quartile	All	1.000	0.612	.027	2	view →
HNSC	DFS	Median	IV	0.920	1.000	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SNAP23–CCRCC (DFS)

Open the CCRCC breakdown →